Linked or semi-related downstream processing delivers significant advancements to productivity, cost, timelines, and facility footprint. Our versatile portfolio lets you end up picking an intensification approach that aligns along with your unique system ambitions.
Allows increased productiveness than standard chromatography, diminished buffer and resin volumes together with decreased resin expenses
Separation variable (alpha) is often a relative comparison on how effectively two neighboring parts in the combination were being divided (i.e., two neighboring bands on a chromatogram). This variable is defined with regards to a ratio on the retention factors of the pair of neighboring chromatogram peaks, and can also be corrected for by the void quantity in the column.
Mechanically prepares buffer remedies with the best combination of pH, conductivity, and focus from stock alternatives. These a few parameters are constantly monitored and managed by a committed algorithm to guarantee accuracy and fast response.
Resolute® BioSC Pilot can connect various methods such as chromatography, viral inactivation and in-line buffer preparing. The chaining of various processes results in a streamlined and intensified process.
A glass reservoir retains the mobile phase ingredient. In HPLC, the flexible stage, or dissolvable, is often a mix of polar and non-polar liquid segments where unique fixations improve dependant upon the specimen here arrangement.
Resolute® BioSC Pilot can hook up numerous steps including chromatography, viral inactivation As well as in-line buffer planning. The chaining of several procedures results in a streamlined and intensified course of action.
Permits simultaneous and continuous operation of up to three chromatography separations. These is often Component of a batch and/or multi-column system
Determine (PageIndex four ) Graph exhibiting the connection amongst the retention time and molecular pounds in sizing exclusion chromatography. Ordinarily the kind of HPLC separation approach to utilize depends upon the chemical nature and physicochemical parameters of your samples.
A linked system is more compact and much easier to regulate. With this webinar, we give an overview on tips on how to configure the Resolute® BioSC.
Sign up for Sartorius as we explore the way to transfer a standalone batch mAb chromatography course of action to the related DSP.
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Every ingredient while in the sample interacts in different ways check here Using the adsorbent product, resulting in distinct migration rates for each part.[three] These distinct rates result in separation as the species circulation out in the column into a certain detector like UV detectors.
The column is in which the separation of analytes normally takes place. It is actually filled with the stationary phase and will vary in duration, diameter, and particle dimensions according to the wished-for separation.